The uterus is divided into 3 layers. The inner layer is the endometrium, the middle is the myometrium, which is the thickest, and the outer layer is a very thin plasma layer. If the endometrium invades the myometrium, it becomes adenomyosis. At present, there is a lack of clear understanding of the causes and pathogenesis of adenomyosis. Trauma to the uterine wall during multiple pregnancies and deliveries and chronic endometritis may be the main causes of this disease. Trauma to pregnancy can cause adenomyosis. Early adenomyosis may have no clinical symptoms or may simply be excessive menstruation, but most patients may experience lower abdominal pain and discomfort, cramping and mild dysmenorrhea. Patients have normal or increased menstrual flow. Any woman with increased menstruation and progressively increasing dysmenorrhea should think about the possibility of this disease. In addition, the disease can lead to infertility. On examination, the doctor will find a uniformly enlarged uterus or a limited nodular bulge with a hard texture and pain on pressure. The diagnosis can usually be made by ultrasound. Adenomyosis is a benign lesion, but it can get worse. For those who are young with fertility requirements, near menopause, unwilling to undergo surgical treatment or whose symptoms recur after conservative surgical treatment, medication or placement of the Mannakol ring can be considered. Commonly used medications include danazol, pregnenolone, oral contraceptives, progestin, mifepristone and gonadotropin-releasing hormone agonists. However, all of these drugs have certain side effects and must be used under medical supervision. Conservative surgical and pharmacological treatment is mostly used for young people with fertility requirements, and early pregnancy is encouraged. If medication does not work or if the dysmenorrhea is prolonged and severe, surgery should be performed. Surgical treatment includes radical surgery and conservative surgery. Radical surgery is hysterectomy, while conservative surgery includes excision of adenomyosis lesions (adenomyoma), hysteroscopic endometrial and myomectomy, and laparoscopic myometrial electrocoagulation. If the patient has no fertility requirements, and the lesions are extensive, the symptoms are severe and conservative treatment is ineffective, combined with fibroids or there are risk factors for endometrial cancer, hysterectomy is appropriate. Moreover, total hysterectomy is preferred to avoid residual lesions. For young patients, the most important concern once they have adenomyosis is whether adenomyosis will cause infertility. It is generally accepted that severe adenomyosis, especially in patients with combined endometriosis, is likely to lead to infertility. These patients have a thick uterus and are prone to pelvic adhesions, which are not conducive to ovulation and embryo implantation, and thus have a low pregnancy rate. Fortunately, it is uncommon for young women to have severe adenomyosis. In cases of mild adenomyosis, there is still a chance of pregnancy. In addition, if a limited adenoma is obtained, the tumor can be surgically removed to preserve the uterus and there is still a chance for future pregnancy. The Manuelle ring, also known as the Manuelle birth control device, has a very small high science and technology progesterone slow release layout, which ensures that after five or six years of placement in the uterine cavity, a small amount of progesterone may be released to the endometrium every day at a constant rate, so that the cervix, the environment of the uterine cavity and the ovarian lining are in a condition unsuitable for conception, thus obtaining an extremely reliable contraceptive effect, and at the same time, because the endometrium is in a dormant state, it also plays a reduce the volume of menstrual blood, shorten the duration of menstrual bleeding and relieve menstrual pain. It should be effective for adenomyosis.