Microscopic lesion nephropathy can usually be recovered in about 4 months after active and standardized treatment, but the specific situation varies from person to person, and it is recommended to take the actual situation as the basis. Microscopic lesion nephropathy refers to a group of glomerular diseases with clinical manifestations of nephrotic syndrome, no obvious pathological changes under light microscopy, and fusion of podocyte peduncles under electron microscopy. The onset of the disease is mostly acute, and the clinical manifestations often include simple nephrotic syndrome, i.e., severe proteinuria, hypoproteinemia, hyperlipidemia, and edema. Microscopic lesion nephropathy seldom resolves spontaneously, so it must be treated aggressively, otherwise it is prone to high mortality due to lipid disorders, atherosclerosis, infection, etc. Glucocorticosteroids are often used clinically to treat microscopic lesion nephropathy. Glucocorticosteroids such as prednisone acetate, methylprednisolone, etc., and immunosuppressants such as cyclophosphamide, cyclosporine, etc., are often used in clinical treatment, and most of the patients can recover after about 4 months of treatment, but there is a big difference between individuals. It is recommended that patients with microscopic lesion nephropathy should consult a doctor in time, follow the doctor’s instructions for standardized diagnosis and treatment, and have regular follow-ups.