Big toe pain extrusion of white pus may be due to trauma, gingivitis and diabetes and other causes. 1. Trauma: If you suffer from trauma when doing sports, which leads to the local soft tissues of the big toe being stung by foreign objects, it may cause swelling and pain in the big toe, and the concurrent infection will lead to the phenomenon of pus flow, so the big toe pain squeezes out white pus. 2. Trenchitis: a suppurative infection of the soft tissues around the nail, caused by bacteria attacking the subcutaneous and growing and reproducing through the minimally invasive breaks in the skin next to the nail. Inguinitis often occurs first in one side of the nail groove subcutaneous, manifested as redness, swelling, pain, if not treated early, the lesion will be pus, so the big toe pain extrusion of white pus. 3. Diabetes: If diabetes is not controlled for a long time, it will cause diabetic foot disease. Once caused by diabetic foot disease, peripheral neuropathy will lead to big toe pain, and easy to induce bacterial infection, which will cause big toe pain extrusion white pus. If the patient big toe pain extrusion white pus, it is recommended to go to the hospital, identify the cause of the disease and follow the doctor’s instructions targeted treatment.