Quadruplex can be successfully sterilized twice after the first failure. Helicobacter pylori infection needs to be given gastric quadruple drugs, usually one time can be successfully sterilized. If sterilization failure may be related to drug resistance, drug time, etc., you can follow the doctor’s instructions to adjust the drug program and drug time, change the drug for the second sterilization. Commonly used antibiotics are amoxicillin, clarithromycin, levofloxacin, furazolidone, tetracycline and so on. H. pylori infection is associated with many stomach disorders, such as gastritis, gastric ulcers, and even stomach cancer. If there is H. pylori infection, it should be actively eradicated with medication. For the first sterilization failure of tetracycline, it is recommended to consult a doctor to analyze the cause and adjust the treatment plan.