Lips are very dry and uncomfortable may be related to physiological causes, such as drinking too little water, bad habits; systemic factors such as lack of vitamin B, taking drugs, etc.; local factors such as exfoliative dermatitis, lichen planus and so on. 1. Physiological causes. (1) Drinking too little water: if because of drinking too little water or the environment is very dry, etc., it may cause serious dehydration in the body, which will lead to very dry and uncomfortable lips. (2) Bad habits: If you have the bad habit of frequently licking your lips or often use poor quality lipstick, it can also cause dry lips. 2. Systemic factors. (1) lack of vitamin B: if the body lacks vitamin B, it can also cause such phenomena. (2) taking drugs: if oral retinoids, such as isotretinoin soft capsules, also easy to cause dry lips peeling. 3. Local factors. (1) Exfoliative lipitis: clinical symptoms are mainly characterized by recurrent dry and flaky lips, dry itching and burning pain. (2) lichen planus: it can also be manifested as a dry and uncomfortable performance of the lips. As you can see, there are many reasons why the lips are very dry, and when they are not relieved by daily care, it is recommended to consult a doctor in time to find out the cause of the disease under the guidance of the doctor for treatment.