A large pimple on the labia can be caused by a variety of reasons. When the vulva is irritated or when no attention is paid to vulvar hygiene and underwear is not changed in a timely manner, it may cause a localized growth on the vulva. There may also be two conditions, one is a Bartholin’s gland abscess and one is folliculitis. The first suggestion is that you can go to the pharmacy to buy complex iodine or iodophor, every night for local disinfection, and then smear a little erythromycin ointment, you can observe 3 days, if there is an effect, the medication will slowly disappear in 7 days. If there is no great effect at the end of 3 days, and there is a tendency to increase, it is recommended to go to the hospital to rule out the presence of Bartholin’s cysts. If there is a Bartholin’s gland cyst, there is no way to get rid of it with any medication. It is recommended to perform an incision and drainage of the Bartholin’s gland cyst to help restore the vulva to normal, so as to avoid prolonged stimulation causing inflammation and upstream infection.