Whether it is better to take Adenosylcobalamin Tablets or Methylcobalamin Tablets has to be evaluated comprehensively according to the specific conditions of the disease suffered by the patient. If it is mainly used for the treatment of peripheral neuropathy, the use of methylcobalamin tablets is more effective, while adenosylcobalamin tablets are more effective when used in anemia. Adenosylcobalamin and methylcobalamin are both members of the B12 family of vitamins, and both are biologically active and directly involved in biochemical reactions within the body. In the treatment of peripheral neuropathy, adenosylcobalamin needs to be converted to methylcobalamin in the human body before it can promote the synthesis of proteins, lecithin and nucleic acids, and its efficacy in the treatment of megaloblastic anemia is better. Methylcobalamin, on the other hand, can be directly utilized by the body without absorption and metabolism, and can lower homocysteine, treat peripheral neuralgia and nourish nerves. If there is a need for medication, it is recommended to choose the appropriate medication for the patient’s condition under the guidance of a physician.