Diclofenac sodium and celecoxib can be taken alternately after relevant drug contraindications are ruled out, but simultaneous administration is not recommended. Diclofenac sodium and celecoxib are both non-steroidal anti-inflammatory drugs, through the inhibition of human cyclooxygenase to play an anti-inflammatory, analgesic effect. Diclofenac sodium is used for the treatment of non-articular soft tissue rheumatic pain, acute attacks of gout and other causes of mild and moderate pain, etc.; celecoxib can be used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults and ankylosing spondylitis. Common adverse reactions with diclofenac include headache and abdominal pain, constipation, diarrhea, heartburn, nausea, and indigestion. Common adverse reactions to celecoxib include abdominal pain, diarrhea, dyspepsia, flatulence, and nausea. Diclofenac is contraindicated in people who are allergic to the drug and in patients with active peptic ulcers and bleeding. Celecoxib is contraindicated in people who are allergic to the drug and those who are allergic to sulfonamides, patients with active peptic ulcers and bleeding, etc. Since both diclofenac sodium and celecoxib are non-steroidal anti-inflammatory drugs, these two drugs can be taken alternatively but are not recommended to be taken at the same time, because the simultaneous use of two or more non-steroidal anti-inflammatory drugs can lead to a higher incidence of adverse drug reactions. Note that NSAIDs should be used in minimized doses and for as long as possible during use. Diclofenac sodium and celecoxib are used under the guidance of a physician, and patients are advised to go to the relevant departments of regular hospitals for detailed consultation.