Tacrolimus ointment can treat cutaneous amyloidosis, but to treat the disease, it is necessary to combine with other drugs according to the patient’s condition, and combine with physical therapy, surgery and other methods of treatment. Cutaneous amyloidosis is a disease related to heredity, sun exposure, trauma, friction, insect bites, and certain systemic diseases, etc. In the treatment of this disease, local topical application of glucocorticosteroids such as clobetasol propionate ointment is the first-line therapeutic strategy, in addition to topical application of tacrolimus ointment, compound salicylic acid preparation and other drugs, and oral loratadine, isotretinoin, and other medications to carry out the treatment. For patients with skin amyloidosis related to sun exposure, oral chloroquine can also be used for treatment; for localized larger rashes, surgical excision can be used for treatment; fractional laser can also be used for treatment. In life, patients should also keep the skin moist and avoid excessive scratching or washing. If the diagnosis of skin amyloidosis is confirmed, please follow the doctor’s instructions for treatment, and medication should be used under the guidance of the doctor.