Early enlargement of the heart can be slowed down by medication and life expectancy may not be affected by regular treatment; however, those with severe enlargement have a shorter life expectancy. Cardiac enlargement is the remodeling of the ventricles, which is an inevitable process in the development of heart failure. Early cardiac enlargement is centripetal hypertrophy, i.e., thickening of the ventricular wall, and late cardiac hypertrophy, i.e., enlargement of the cardiac chambers. Patients with centripetal hypertrophy have less impairment of cardiac function, and scientific drug treatment can largely slow down the development of the disease, which has little impact on life expectancy, and if the disease is well controlled, the patient can survive for several years to several decades. Patients with isolated cardiac hypertrophy have poorer cardiac function, and the decline in ejection function of the heart is obvious and more severe, with significant symptoms of heart failure. These patients have a shorter survival period and require rigorous treatment and care to prolong survival and reduce mortality. The presence of cardiac enlargement, need to actively consult the doctor, follow the doctor’s advice and reasonable treatment.