High transaminases need to identify the cause of the disease, such as physiological, hepatitis, gallstones, etc., according to the cause of the disease to be treated, such as taking hepatoprotective drugs, antiviral, antibiotics and other drugs treatment. 1. Physiological high transaminase: such as tiredness, drinking alcohol, after strenuous exercise can make transaminase mildly elevated. Physiological elevation need not worry too much, after stopping the above triggers can return to normal. 2. Hepatitis: Viral hepatitis, such as hepatitis B, can cause transaminases to rise, requiring the use of antiviral drugs, such as entecavir, etc., and hepatoprotective drugs, such as glutathione, etc., for treatment. 3. Gallstones: due to bile duct obstruction, bile stagnation can make transaminase high, this time you can take ursodeoxycholic acid tablets and other choleretic treatment, if necessary, surgical treatment. The above drugs need to be taken under the guidance of a professional physician, as soon as possible to identify the cause of the disease, do not blindly use drugs.