The reason why the patient has peripheral discomfort is firstly to consider whether the patient has an elevated body temperature, secondly, staying up late or being fatigued will also cause peripheral discomfort, and finally many diseases may also cause the patient to have peripheral discomfort. Therefore, the patient should be examined promptly to exclude organic diseases that cause the patient to have such symptoms. Patients can have their body temperature and blood pressure tested as well as routine blood tests, liver function, kidney function, and abdominal ultrasound if necessary, to rule out the presence of more serious diseases. In general, there is no need to worry too much. After ruling out organic diseases, consider that it may be related to the state of subhealth, pay attention to rest, avoid exertion, stay up late, relax emotionally, and ensure sufficient sleep time and sleep quality.