Increased pulse pressure difference in patients with acute left heart failure may be caused by aortic closure insufficiency, which can be treated by general treatment, medication and surgery. 1. General treatment: Limit heavy physical labor, keep sitting position, make legs in the state of sagging, can reduce the venous return blood volume, help to reduce the load on the heart, relieve the symptoms, diet with low salt and low fat, light diet, give oxygen. 2. Drug therapy: positive inotropic drugs such as digoxin, sodium nitroprusside and nitroglycerin can increase myocardial contractility and relieve the symptoms of heart failure. Diuretics such as furosemide and hydrochlorothiazide can promote urination and reduce the burden on the heart. 3. Surgical treatment: once there is obvious left heart failure, should be immediately or as soon as possible surgical treatment, such as through artificial valve replacement to restore heart function, aortic valve repair surgery to remove excess valve tissue, to solve the situation of increased pulse pressure difference. It is recommended to go to the hospital in a timely manner, under the guidance of the doctor’s treatment, not to blindly use their own medication, to prevent delays in the condition, resulting in other damage.