Acyclovir cream is a purine nucleoside antiviral drug, herpes sweat is not caused by viruses, thus it is not suitable for herpes sweat. 1. Acyclovir cream’s main ingredient is acyclovir, which can inhibit viral replication, and has an inhibitory effect on herpes simplex virus, varicella zoster virus, cytomegalovirus and so on. 2. The etiology of herpes sweat is not yet completely clear, now it is believed that herpes sweat is a kind of eczema-like reaction, mental factors, local infections, allergies or irritation and neurological dysfunction and so on may be related to this disease, but the virus is not the causative factor of this disease. Thus, acyclovir ointment has no therapeutic effect on it. The medicines for the treatment of sweat herpes include benadryl, tretinoin urea ointment, tacrolimus ointment and so on. Patients are advised to take treatment under the guidance of a professional doctor, and never self-medicate to avoid adverse reactions.