Shortness of breath in chest tightness is considered to be related to physiological factors, environmental factors, as well as respiratory system diseases, digestive system diseases, cardiovascular diseases and other disease factors. 1. Physiological factors: prolonged work pressure or overwork can also lead to symptoms of chest tightness and shortness of breath, usually after removing the triggers, the symptoms can be relieved on their own, and secondly, during pregnancy, with the development of the fetus, the uterus increases in size, and the uterus squeezes the surrounding organs, which will also cause symptoms of chest tightness and shortness of breath. 2. Environmental factors: too much time in a space with poor air circulation and relatively confined environment can also cause chest tightness and shortness of breath. 3. Disease factors: (1) respiratory diseases: such as acute upper respiratory tract infection, bronchitis, etc., can be manifested as chest tightness and shortness of breath with cough, dyspnea, wheezing after exercise. Bronchial asthma, trachea, bronchial congenital developmental abnormalities, various causes of pleural effusion, pneumothorax, foreign body aspiration, etc. can cause chest tightness. (2) Digestive system diseases: gastroesophageal reflux is the most common, which can be manifested as chest tightness and shortness of breath, chest pain, retrosternal burning sensation, acid reflux, and in some cases, chronic cough. (3) cardiovascular disease: myocardial ischemia, cardiac insufficiency related, because lying down will make the amount of return blood has increased, easy to increase the burden on the heart, will aggravate the lungs bruises, there will be chest tightness and shortness of breath symptoms. Causes of chest tightness and shortness of breath are very complex, disease factors caused by patients need to be treated under the guidance of a doctor.