Darkening of the skin after blood transfusion is generally not directly related to blood transfusion, but it cannot be ruled out as a result of iron overload. If it is caused by iron overload, iron needs to be discharged from the body through medication, which can be done by taking Deferasirox dispersible tablets under the guidance of a doctor, or by intravenous drip to promote iron discharge. The darkening of skin after blood transfusion may be caused by anemia itself, which makes the patient’s face look waxy and dark, or it may be related to other factors such as excessive sun exposure, etc. Attention can be paid to skin moisturizing and sun protection, and the patient’s primary diseases can be treated by actively correcting the anemia and treating the patient’s primary diseases. Blood transfusion treatment needs to be carried out in the hospital, patients with blackened skin after blood transfusion should inform the doctor in time to find out the cause and then deal with it.