1. Does short-acting contraceptive pill (hereinafter referred to as COC) cause weight gain in women? Theoretically, sex hormones may cause weight gain through different mechanisms, such as the water and sodium retention effect of estrogen; the appetite stimulating effect of progestin; and the protein assimilation effect of androgen. However, studies have shown that weight gain in COC users alas did not exceed the range of physiological changes, while drospirenone in Eusebio has an anti-salt corticosteroid effect and better control of weight than the control group. Sun Jianmin, Department of Obstetrics and Gynecology, Putuo District Central Hospital, Shanghai, China 2. Does COC increase acne or cortical overflow? No. Nowadays, progestins in short-acting contraceptives have anti-androgenic activity, especially Da Ying 35. 3. Does COC increase the occurrence of cardiovascular disease? COC increases the risk of VTE (venous embolism). the risk of VTE is highest in the first 4 months after taking COC and decreases thereafter. The risk of VTE is highest in the first 4 months and decreases thereafter. It returns to pre-drug levels 3 months after discontinuation. 4. COC and malignancy COC can reduce the occurrence of ovarian cancer and endometrial cancer. There is no significant increase in the risk of breast cancer. There may be an adverse effect on the occurrence of cervical cancer, but the role of HPV infection leading to cervical lesions needs to be excluded. 5.Does COC reduce women’s fertility? COC is a reversible contraceptive method, and fertility can be restored after stopping the drug. At the same time, COC can also provide protection for women’s fertility through three effects. (1) COC has a definite contraceptive effect, effectively reducing the incidence of unwanted pregnancies and abortions. (2) COC is effective in suppressing ovulation, which can reduce the occurrence of ectopic pregnancy. (3) The inhibitory effect of COC on cervical mucus can effectively stop the upward movement of acute infection in the lower genital tract and reduce the occurrence of pelvic infection. The negative effect of age on pregnancy was not increased in women with previous COC use. The time frame of previous COC use also had no significant effect on fertility after discontinuation of the drug. 6. COC and pregnancy? Pregnancy is possible after discontinuation of short-acting COC without waiting 3 to 6 months. There is no need to terminate pregnancy within a short period of time after discontinuation. 7.Inappropriate use of COC during pregnancy? Studies have shown that there is no correlation between the use of oral contraceptives in early pregnancy and physical defects in newborns. The short-acting oral contraceptives mentioned here are now the third generation oral contraceptives, such as Mafulon, Daing 35, Ursine, Tegucel, etc.