Progesterone is a hormone secreted by the ovarian gestational corpus luteum in the body of a pregnant woman, and progesterone ensures the smooth progress of pregnancy. Currently, many pregnant women are found to have low progesterone levels in the early stages of pregnancy. The treatment for low progesterone needs to be determined by the absence of clinical symptoms. If there are no clinical symptoms, then no medication is needed for the time being. Pregnant women are advised to take regular progesterone tests to observe the changes in progesterone indicators and to test for changes in serum human chorionic gonadotropin. If the trend of serum human chorionic gonadotropin increase is normal, it proves that the embryo is developing well and can continue to be observed. If the pregnant woman has symptoms such as vaginal bleeding or lower abdominal pain, then it is recommended to give progesterone supplementation. Oral progesterone can be chosen to supplement progesterone. If the progesterone level drops severely, progesterone injection can be given intramuscularly at the same time. During the treatment period, observe changes in the amount of vaginal bleeding and monitor changes in progesterone levels. When symptoms such as vaginal bleeding disappear, progesterone supplementation therapy can be stopped. To summarize, the treatment of low progesterone depends on whether the patient has clinical symptoms or not, to increase the pertinence of the treatment and avoid blind treatment.