Burning sensation behind the sternum is usually related to physiological factors, reflux esophagitis, infectious costochondritis, etc. It can be treated with temporary observation, general treatment or surgery according to the cause. 1. Physiological factors: For example, eating spicy and stimulating food or drinking alcohol may cause burning sensation behind the sternum. Symptoms will be relieved by themselves after staying away from the causative factors. No special treatment is needed and temporary observation is allowed. 2. Reflux esophagitis: When acid or alkali refluxes into the esophagus, causing damage to the mucous membrane of the esophagus, it may cause burning and the symptoms may radiate to the back of the sternum. It should be treated with acid-suppressing drugs, such as omeprazole, as soon as possible. If there is gastrointestinal indigestion and flatulence, it should be treated with gastric stimulants, such as domperidone. It is recommended to elevate the head of the bed at night to reduce reflux. 3. Infectious costochondritis: Inflammation of the costochondral cartilage affects blood circulation and leads to edema of the soft tissues, which will cause chest pain and a distinct burning sensation. After diagnosis, surgery should be done as soon as possible to remove the diseased rib cartilage, and then oral antibiotics to reduce inflammation, such as cefixime, ceftriaxone sodium, cefradine, etc.. Regarding the burning sensation behind the sternum, it is recommended to observe first, and if the symptoms last for a long time, it is recommended to consult a doctor in time and make diagnostic analysis by doctor’s examination, laboratory tests, and imaging tests are needed if necessary. Drugs need to be used under the guidance of a doctor, avoid self-medication.