Children in the middle of the night toothache may be caries caused by pulpitis, periodontitis, etc., you can take general treatment, or ibuprofen and other drugs to relieve the pain, such as not relieving timely medical care. 1. General treatment: toothache in the middle of the night, because there is no emergency dentistry, so it is difficult to emergency dentistry to deal with the pain. Parents can help their children at home themselves by making some ice cubes, wrapping them in a towel and applying a cold compress to the affected side of the face. Or take ice water, both of which help to relieve pain. 2. Medication: Ibuprofen is a non-steroidal anti-inflammatory drug, which has a good pain-relieving effect on toothache, and can be taken orally in an emergency to relieve pain. If not relieved, consult a doctor in time. If the toothache is caused by pulpitis, root canal treatment or tooth repair can be taken. Periodontitis can use boron cream to relieve inflammation and pain. There are many other reasons for children to have toothache in the middle of the night, it is recommended to consult a doctor for examination in a timely manner, according to the results of the examination to formulate a diagnosis and treatment plan, the above medication needs to be used under the guidance of a doctor.