Lupus erythematosus can have an effect on pregnancy and childbirth. If lupus erythematosus is non-remitting, patients are prone to miscarriage, preterm labor, or stillbirth, so contraception should be used. From the first trimester to pregnancy, if the application of cyclophosphamide, methotrexate, azathioprine can affect the growth and development of the fetus, it is necessary to discontinue the use of the above drugs for at least three months before pregnancy. Pregnancy can trigger the activity of lupus erythematosus, especially in early pregnancy and six weeks postpartum, patients with a history of habitual abortion or positive antiphospholipid antibodies should take low-dose aspirin during pregnancy, and low-dose glucocorticosteroids, such as prednisone 20-30mg/d, will be inactivated when they pass through the placenta, and will not cause damage to the fetus. Lupus erythematosus is not allowed to become pregnant until there is no serious damage to the central nervous system, kidneys or heart, and the disease has been in remission for more than six months.