People often ask: I have been using one antihypertensive drug for many years, do I need to change to another drug? Will I be resistant to one medication after using it for a long time? Will there be any side effects if I use one drug for a long time? My answer is: No. As long as the blood pressure is satisfactorily controlled and no adverse reactions occur, there is no need to change the antihypertensive medication. Generally speaking, the side effects of antihypertensive drugs will show up after the first few weeks of use. If no adverse reactions occur after a long period of time, it means that the patient can tolerate the drug well, so there is no need to worry about the side effects of using a drug for a long time, and there is no need to change the drug. A basic principle of antihypertensive treatment is to control blood pressure in a long-term, lasting and smooth manner. Frequent changes of antihypertensive drugs can lead to blood pressure fluctuations, which can have adverse effects on the heart, brain and kidneys. The advantage of these drugs is that they only need to be taken once a day, which is convenient for long-term adherence to treatment. At the same time, the application of long-acting drugs can also reduce blood pressure fluctuations, so that blood pressure is reduced smoothly. These long-acting drugs have another characteristic: they do not have a significant blood pressure-lowering effect immediately after taking them, and require 2-3 weeks of continuous use before they take full effect. This feature ensures a gradual and steady decrease in blood pressure, as a rapid and significant drop in blood pressure in a short period of time can be detrimental to the patient. Therefore, those who have just used the medication should not be in a hurry and need to adhere to the medication for 2-3 weeks before judging how effective it is. Some people use a drug for only two or three days, feel that the blood pressure does not drop significantly, then consider it ineffective, switch to other drugs, this is not reasonable. If the blood pressure is only mildly to moderately elevated, there is no need to urgently lower the blood pressure, and the effect of treatment should be evaluated after at least one or two weeks of observation after starting the medication. Not long ago about individual pharmaceutical companies to provide raw materials produced by the valsartan and other sartan drugs may contain carcinogens once the news broke, quickly make a lot of patients are worried, unauthorized to stop the drug to change the few people. Of course, this news is not unprecedented, but most lay people do not understand the context of the incident, leading many to misunderstand all sartans. Newly, the BMJ published an article stating that the Prilosec class of antihypertensive drugs may increase the risk of lung cancer. Many heavyweight studies with significant clinical value are rarely publicized and presented, but the conclusions of such negative studies are spreading at an exponential rate, again causing panic among hypertensive patients. In fact, from a professional point of view, such retrospective studies are subject to many confounding factors, their strength of evidence is weak, their scientific value is very limited, and professionals rarely appreciate and savor them as a new dish. Nonetheless, many people who know the truth or are unaware of it are spreading the news like flies laying eggs, intentionally or unintentionally, without considering how such behavior could adversely affect hypertensive patients and the prevention and control of hypertension in our country. It is important to note that the efficacy and safety of Prilosec has been repeatedly demonstrated in dozens of international multicenter randomized controlled clinical trials, and a series of post-marketing studies have fully demonstrated that it is an excellent antihypertensive drug. A retrospective study alone does not tell us much, and should not influence the development of clinical treatment plans. After taking antihypertensive drugs, some patients may experience dizziness, headache, fatigue, lack of concentration and other symptoms similar to hypotension due to lower blood pressure. Please pay attention to the blood pressure measurement when you encounter this situation, as long as the blood pressure is not low, it does not matter and you do not need to worry too much, the above symptoms will disappear after a few weeks of adherence to treatment, so do not stop the medication. For patients with hypertension, try to choose long-acting antihypertensive drugs for initial treatment, with small to large doses, and try to gradually control the blood pressure below the target value within a few weeks, so as to reduce the discomfort caused by the lowering of blood pressure. Short-acting drugs have a rapid hypotensive effect, and blood pressure can be lowered rapidly within a few hours after taking the drug. Many patients experience discomfort, so try to avoid them.