Rivaroxaban can usually be taken at the same time as amoxicillin. Rivaroxaban is a medication that can play an important role in the coagulation cascade, and is used to prevent venous thrombosis in people undergoing elective hip or knee replacement surgery, as well as for the treatment of deep vein thrombosis in adults and for pulmonary embolism. Amoxicillin, on the other hand, is a penicillin antibiotic drug that can be used to treat infectious diseases caused by pathogens that are sensitive to the drug. Adverse reactions such as gastrointestinal disturbances and skin rashes may occur with the use of the drug. Use with caution if you are allergic to penicillin. The instructions for rivaroxaban do not specify that the drug is prohibited for use with amoxicillin, so individuals can use both rivaroxaban and amoxicillin under the supervision of a physician for the treatment of related conditions, if necessary. Before using rivaroxaban, it is important to note that the drug must be contraindicated in people who are allergic to any of the components of the drug, people with clinically significant active bleeding, people with a significant risk of hemorrhage, pregnant women, and breastfeeding women. Also the use of the drug may cause some adverse reactions, commonly bleeding, abdominal pain, back pain, insomnia, itching of the skin. Individuals are advised to use rivaroxaban as well as amoxicillin in strict compliance with medical advice and never abuse it, and to inform their physician if they experience any abnormalities during the use of the drug.