5-year-old children sleep and wake up with swollen eyelids, may be related to physiological factors, may also be due to insect bite dermatitis, kidney disease and other lesions caused by factors. 1. Physiological factors: 5-year-old children who drink a lot of water at night before going to bed, cry or stay up too late at night, resulting in insufficient sleep, may cause children to sleep and wake up with swollen eyelids. 2. Insect bite dermatitis: hot summer, due to more mosquitoes, if there is no good anti-mosquito care, sleep at night leads to 5-year-old children by mosquito bites, it is easy to cause sleep and get up eyelid swelling, but also can be accompanied by obvious eye itching, pain and other uncomfortable symptoms. 3. Kidney disease: common in nephrotic syndrome, glomerulonephritis and other diseases, if a 5-year-old child suffering from the above diseases, the child’s renal filtration capacity is weakened, resulting in the body of water can not be discharged in a timely manner, but rather infiltration into the tissue interstitial space, which may lead to swelling of the eyelids of the child to get up after sleeping. It is recommended that children with significant eyelid swelling be seen by a physician for evaluation and treatment.