In clinical work, we often encounter patients’ families asking questions such as “Is schizophrenia hereditary? How did he get this disease?”, “No one in our family has ever had a mental illness?”, “Can he get married?” “Can he get married?”, “Can he get married?” , “Will my child get schizophrenia in the future?” And so on. Faced with the anxious expressions of the patient’s family, it is not difficult to answer these questions, as long as we know what is a genetic disease? What is a genetic predisposition? A genetic disease is a disease caused by a change (mutation or aberration) in the genetic material, referred to as a genetic disease. Genetic diseases are usually hereditary, lifelong, familial, and congenital. For example, Queen Victoria’s family in England in the 19th century was a famous family of hemophiliacs. Among the Queen’s descendants, those with hemophilia passed on the disease to some royal families in Europe through the marriage of daughters who carried the disease-causing gene, resulting in a series of hemophiliacs and hemophilia gene carriers. A large number of domestic and international genetic studies of schizophrenia can only show that the occurrence of schizophrenia is genetically related, but cannot conclude that schizophrenia is a genetic disease. From the data of genealogical surveys on schizophrenia, it was found that the prevalence of schizophrenia among family members of psychiatric patients was 6.2 times higher than that of the general population, and the chance of having children with schizophrenia was 16.4% when schizophrenic patients were married to healthy people, and 39.2% when both men and women were schizophrenic. Thus, schizophrenia does have a genetic predisposition, but not all children born to schizophrenic patients have schizophrenia. Therefore, it is recommended that patients of childbearing age may marry, but should not have children. The current consensus view of psychologists is that schizophrenia occurs as a result of a combination of genetic qualities and biological and psychosocial factors in the environment. Therefore, we should provide a good living and working environment for these susceptible people in our daily work and life, and reduce the adverse stimulation to them, so as to reduce the incidence and relapse rate of schizophrenia.