Symptoms of lung cancer in advanced stage at the time of death include:1. Patients with brain metastasis often have limitation of limb activity or paralysis, cognitive dysfunction, sensory abnormality, and even tumor hemorrhage, and die of acute stroke.2. Patients with bone metastasis often have uncontrollable neuropathic severe cancer pain, pathologic bone fracture, nerve compression, spinal cord compression, hypercalcemia and so on, and the patients show anxiety, depression, disappointment, loneliness and despair. Hypercalcemia is one of the causes of death of lung cancer bone metastasis, and the temporary pre-symptoms include blurring of consciousness, coma, convulsions and so on.3. Cardiac tamponade, if rescue is not timely, will end up with poor blood supply to vital organs, cerebral ischemia, hypoxia, respiratory difficulties, so as to be comatose, and die of cardiac arrest.4. Acute pulmonary embolism patients often present with chest pain, respiratory difficulties and hemoptysis, and ultimately die because of hypotensive shock. Death.