How to treat invasive breast cancer with mid-term 2-negative and 1-positive? It needs surgical treatment, chemotherapy, targeted therapy, and some patients also need radiotherapy. 1. Surgery: After breast cancer occurs, if there is no contraindication to surgery, surgery is usually needed, and modified radical mastectomy is feasible. 2. Chemotherapy: chemotherapy drugs are injected into the vein, which can kill the residual cancer cells and determine the recurrence rate of breast cancer. 3. Targeted therapy: 2-positive and 1-negative refers to the positivity of progesterone receptor and estrogen receptor, while the negativity of human epidermal growth factor receptor, at this time, targeted therapy is feasible. 4. Radiotherapy: It needs to irradiate the operation area with rays, which can kill the residual cancer cells and thus improve the cure rate. It is recommended to go to regular medical institutions for consultation, and comprehensive judgment of the condition is needed before a treatment plan can be formulated.