Stem cells can be used to treat the sequelae of cerebral infarction, but at present, this is still in the research stage and has not been promoted to the clinic. The possible mechanisms of stem cell transplantation for the treatment of sequelae of cerebral infarction and its precautions are as follows: 1. Activate nerve cells: Stem cells secrete neurotrophic factors, reduce apoptosis of nerve cells, promote regeneration of blood vessels in the transplanted area, and activate the recipient’s own nerve stem cells, dormant nerve cells and damaged nerve cells, thus improving clinical symptoms. 2. Reduction of brain atrophy: neural stem cell transplantation can also reduce the area of infarct foci, not because the transplanted cells fill up the infarct foci, but because these cells secrete a variety of neurotrophic factors to reduce secondary brain atrophy. 3. Immune rejection: immune rejection also exists in brain tissue, so it is still necessary to use immunosuppressant at the time of transplantation. Stem cell treatment of cerebral infarction sequelae needs further clinical research, the treatment of cerebral infarction sequelae need to seek professional physician’s consultation, so as not to delay the condition.