Serum igg-negativity usually refers to the failure to detect relevant antibodies in the serum. It may usually occur in the early stage of viral infection, false-negative viral IgG antibody test, false-positive viral nucleic acid test, and so on. 1. Early stage of viral infection: If the patient is indeed infected with a certain virus, and the serum antibody IgM test and IgG test are both negative, it suggests that the patient is now in the early stage of infection, and the body has not yet produced the corresponding antibodies, especially the IgG antibody, which usually appears relatively late. 2. False-negative viral antibody IgG test: If the patient is diagnosed with a certain viral infection, but the antibody IgM test is negative and the IgG test is negative, it usually suggests that the negative antibody test is false-negative. 3. False-positive viral nucleic acid test: If the patient’s serum antibody IgM, IgG test continues to be negative, the patient is diagnosed with a certain viral infection through the positive nucleic acid test, so it can be deduced that the patient’s positive nucleic acid test is false-positive, the patient is not a certain viral infection, otherwise it is impossible to continue to be negative serum antibody IgM, IgG. If you test positive for a certain virus antibody and symptoms of viral infection, you need to consult a doctor in time, complete other tests under the guidance of a physician, and make a comprehensive judgment based on the results.