Irbesartan Tablets and Nifedipine Controlled Release Tablets can be used in combination and should be used in accordance with medical advice. Irbesartan Tablet belongs to a kind of angiotensin-II receptor antagonist, which has the effect of lowering blood pressure, the treatment of essential hypertension, and can also be used in type 2 diabetic nephropathy combined with hypertension. Adverse effects of this product include dizziness, nausea, vomiting, fatigue, upright hypotension, and skeletal muscle pain. This product is contraindicated in people who are in the 4th to 9th month of pregnancy, those who are allergic to the ingredients of this product, and those who are breastfeeding. Nifedipine controlled-release tablets belong to a kind of calcium antagonist blood pressure-lowering drug, which can be used for coronary heart disease, chronic stable angina, hypertension. Adverse effects of this product include edema, headache, feeling unwell, vasodilation, constipation. The drug is contraindicated in 20 weeks of pregnancy, lactating women, people who are allergic to the product, cardiogenic shock. Irbesartan tablets can be safely combined with calcium antagonists such as nifedipine controlled-release tablets without drug interactions, and can be taken together, but with medical advice.