Possible causes of multiple substantial masses in the liver include primary hepatic malignant tumors, hepatic metastases, and benign hepatic tumors. 1. Primary hepatic malignant tumor: hepatic malignant tumors include hepatocellular carcinoma, intrahepatic cholangiocellular carcinoma, mixed malignant tumors, hepatic sarcoma and so on, among which hepatocellular carcinoma is the most common. 2. Liver metastases: liver is one of the organs with the richest blood supply, thus malignant tumors in other parts of the body can easily be transferred to the liver through the bloodstream, among which malignant tumors of the digestive system are the most common ones, such as gastric cancer, pancreatic cancer, colorectal cancer and so on, which are easy to be metastasized to the liver and form multiple substantial metastatic foci. 3. Benign liver tumors: including hepatic cavernous hemangioma, hepatic adenoma, hemangioendothelioma, lipoma, etc. Cavernous hemangioma is common. It is recommended to go to the hospital as soon as possible to consult the doctor to clarify the nature of the mass in time and then give targeted treatment.