Zoledronic acid can inhibit the activity of osteoclasts and induce their apoptosis, prevent the release of bone calcium as well as bone reabsorption, and is used for the treatment of bone damage in patients with multiple myeloma and bone metastases of tumors, as well as hypercalcemia induced by malignant tumors. Side effects such as bone pain, nausea, fever, vomiting, fatigue, chills, anemia, arthralgia, headache, hypocalcemia and renal impairment may occur. Blood calcium concentration should be tested before using the drug, and if there is hypocalcemia, it should be corrected and appropriate vitamin D supplementation should be provided, and blood calcium, phosphorus, magnesium, creatinine and other indexes should be closely detected during the period of using the drug. The drug should not be used with infusion fluids containing divalent cations, such as lactated Ringer’s solution, and there are interactions with thalidomide and other drugs, so you should consult a medical professional before use. It is contraindicated in pregnant and lactating women; it is contraindicated in those who are allergic to the drug or other bisphosphonates. If you need to use the drug, please strictly follow the doctor’s instructions under the guidance of the medication, do not self-medication.