Anti-sperm antibody positive is due to the body’s immune response, the cause of the disease is not clear, if men have anti-sperm antibody positive may be caused by viral infections, trauma and so on. If a woman is positive for anti-sperm antibodies, it may be due to vaginitis or salpingitis. Anti-sperm antibodies mean that the phagocytes in the body recognize sperm as a foreign body and stimulate the body to have an immune response, thus producing corresponding antibodies. However, the cause of positive anti-sperm antibodies is still unclear. If a man is positive for anti-sperm antibodies, it is mostly considered to be related to viral infections, trauma, immune factors, local inflammatory infections and other factors. Ten percent of the male infertility population is positive for anti-sperm antibodies. In women, the possibility of having positive anti-sperm antibodies is increased by the presence of inflammation of the reproductive system, such as vaginitis, salpingitis, endometritis and other inflammatory diseases. In addition, women who are allergic to male sperm can also develop anti-sperm antibodies, which does not mean infertility. It is recommended that the organism with positive antisperm antibodies needs to seek medical attention, and the doctor will choose the appropriate measures for treatment according to the cause of the disease.