The probability of brain metastasis from oral squamous cell carcinoma is low and there are no specific data available. Oral squamous cell carcinoma is a malignant tumor that occurs in the oral cavity and has a pathologic type of squamous cell carcinoma. Diseases such as lip cancer, gum cancer, tongue cancer, and cancer of the floor of the mouth all fall into the category of oral squamous cell carcinoma. If the patient’s disease is detected earlier and in early stage, after active treatment, the probability of clinical cure is relatively high and the prognosis is good, and the probability of brain metastasis is relatively low at this time. If the patient’s disease is detected late and diagnosed in the middle or late stage, the probability of brain metastasis will increase, but the common site of metastasis is the lungs, and brain metastasis is less common. It is recommended that patients actively cooperate with the doctor’s treatment, which can improve the prognosis of patients through early detection, early diagnosis and early treatment.