Non-obstructive azoospermia is not due to ductal obstruction, it is due to testicular factors and fails to produce spermatozoa, the clinical manifestations are related to the classification as follows: 1, due to chromosomal aberrations, such as Kirschner’s Syndrome or Congenital Testicular Hypoplasia Syndrome, the patient has a special face, and after the physical examination, it is found that the testes are very small, and due to chromosomal aberrations do not produce spermatozoa; 2, the patient’s chromosomes are normal but after the physical examination of the doctor, it is found that the testes are relatively small, below 8 ml or even the size of the fava beans or mung beans, and it is basically loss of spermatogenesis, and it can not allow the woman to get pregnant at all.