Diarrhea, burping with sour smell, may be related to acute gastroenteritis caused by indigestion and other diseases, usually treated with medication. Acute gastroenteritis is an inflammatory injury to the gastrointestinal mucosa due to a variety of reasons such as intestinal infections, improper diet, and exposure to cold. Clinical manifestations are mainly diarrhea, abdominal pain, but also nausea, vomiting. Due to gastrointestinal dysfunction so food is not well digested in the gastrointestinal tract, so it may ferment and burp to produce a sour odor. Acute gastroenteritis can be treated with appropriate antibiotics based on the results of drug sensitivity tests. Commonly used are levofloxacin and cefadroxil, etc. For patients with diarrhea, antidiarrheal drugs such as montelukast can be given. It can also be combined with aluminum sulfate, lactobacillin tablets to improve the internal environment of intestinal flora and protect the intestinal mucosa. The above drugs are for reference only and should be used in accordance with medical advice. If you have diarrhea, burping with sour smell, it is recommended to consult a doctor for further examination, and to clarify the cause with the help of the doctor and carry out targeted treatment or therapy.