Rectal mucosal erosion with perianal itching may be due to rectal type ulcerative colitis, proctitis, etc., and requires medication or surgical treatment. Rectal mucosal erosion may be due to rectal ulcerative colitis, proctitis, etc. When localized intestinal mucosal erosion occurs with infection and other symptoms, perianal itching and other symptoms may occur secondary. In addition, perianal itching can also be caused by perianal skin and mucous membrane breakage and infection, ascariasis, etc. The cause of the disease is more complex, and it is recommended to go to the hospital to receive systematic examination and treatment. For rectal ulcerative colitis, you can use LiuZiShiPi, Prednisone, azathioprine and other drugs for treatment; for proctitis need to be based on the cause of the drug, such as bacterial infection, you can choose to cefuroxime, levofloxacin, and other drugs for treatment; for the perianal skin and mucous membrane damage can be used to use erythromycin ointment, etc. for local treatment; and ascariasis need to use Albendazole and other deworming drugs treatment. Rectal mucous membrane erosion with perianal itching, it is recommended to go to the hospital in time to avoid delaying the condition; the above drugs need to be used under the guidance of clinicians.