Blisters on the skin of the mouth may have several causes: first, herpes simplex caused by the herpes virus. Anti-viral treatment is available, commonly used drugs are acyclovir, vevaciclovir, ganciclovir. If necessary to improve the body’s resistance, commonly used drugs are levamisole transfer factor, pidomod or thymidine. Blistering of the mouth skin may also produce mucous gland cysts, which are caused by bad habits such as lip biting, and require surgical removal for treatment and maintenance of oral hygiene. If oral hygiene is poor, it is not conducive to healing, while it is recommended to use mouthwash, commonly used with compound chlorhexidine gargle, you can also use rehabilitation new liquid or compound thick tinidazole gargle, etc. Herpes simplex can be self-limiting without medication and can heal on its own in about 7-10 days.