When white pustules appear under the lips, the number and appearance of the pustules need to be carefully observed. If the number of pustules is not large and they are purely under the lips, it is considered to be pustules in the perioral area formed by incandescent stomach fire. Considering that it is caused by bacterial infection factors, you can choose to go to the local hospital to do bacterial culture plus drug sensitivity test, you can choose sensitive oral medication, and if necessary, you can take oral Qing Huo Zhi Mai tablets to clear the stomach fire and achieve the ideal treatment effect. If the number of growing white pustules is not much, with papule-like changes and painful pressure, it is considered to be acne in the perioral area. It is recommended to choose oral minocycline with topical adapalene gel, eat less chili and reduce staying up late to prevent the symptoms from worsening.