Parkinson’s disease is a common disease among middle-aged and old people, especially the elderly. At present, the prevalence rate of people over 65 years old in China is 1.7%, and about 1.7 million people over 55 years old suffer from the disease. Parkinson’s disease is a degenerative disease of neurons in the substantia nigra striata of the brain. The cause of the disease is not clear, and it is generally believed that it may be related to human aging, environmental toxins (pesticides, herbicides), genetic factors, and so on. The disease has an insidious onset and a long course. The familiar resting limb tremor is a clinical feature of Parkinson’s disease and an important piece of evidence in diagnosing Parkinson’s disease. However, once a patient with Parkinson’s disease develops the characteristic symptoms such as tremor, the nigrostriatal dopamine neurons in the brain have been reduced by 60% to 70%, and the striatal dopamine neurons have been reduced by 80%. Studies have found that atypical clinical manifestations are present 10 to 15 years before the patient presents to the doctor with symptoms. There were non-motor health problems 3 to 5 years before the diagnosis of Parkinson’s disease. After the diagnosis of Parkinson’s disease, the use of levodopa-based medications for Parkinson’s disease is effective for about 5 years or more, and there are no tangible therapeutic agents available if the nigrostriatal dopamine neurons in the brain continue to decrease. As a result, the long-term prognosis for Parkinson’s disease is poor. If Parkinson’s disease can be recognized early, early intervention can be carried out, and brain tissue can be actively protected, it may be possible to delay its progression, thus delaying the use of medication and improving the quality of survival of patients. 1. Two Types of Symptoms of Parkinson’s Disease Clinical symptoms of Parkinson’s disease can be categorized into two types, i.e. motor symptoms and non-motor symptoms. 1.1 Motor symptoms – the main symptoms of Parkinson’s disease: Parkinson’s disease typical clinical features are: resting tremor, ankylosis, bradykinesia, reduced linkage movements, postural instability (balance disorders: for forward and backward tilt; forward posture, small broken steps). The appearance of the above four main symptoms is already in the middle or late stages of the disease. It is now believed that before Parkinson’s disease presents with limb tonus, delayed movement, decreased movement, and resting tremor, patients can present with other symptoms of abnormal brain function. Recognizing these symptoms can help patients identify Parkinson’s disease early. 2, non-motor symptoms of Parkinson’s disease 2.1 Sensory abnormalities: often present with olfactory disturbances (which require special tests to detect) or decreased sense of taste, pain (headache, back pain), numbness, restless legs syndrome, etc. Visual symptoms. 2.2 Personality changes: the patient’s personality may change. 2.3 Cognitive impairment: memory loss (forgetting what just happened, forgetting to do what was planned), dementia can occur in advanced stages. 2.4 Sleep disorders: poor sleep, easy to wake up, ocular fast-moving sleep behavior disorder, daytime sleepiness. 2.5 Abnormalities of autonomic function: abnormalities of urination and defecation (constipation, feeling of incompletion, frequent nocturia, urinary urgency, urinary incontinence), abnormalities of thermoregulation, abnormalities of sweating, postural hypotension, salivation, etc. 40% of Parkinson’s disease patients have postural hypotension. 2.6 Mental-affective disorders: depression, anxiety, hallucinations, existential feelings, etc.. Among them, the incidence of anxiety and depression is high, about 50%. In addition, it has been suggested that about 5% of Parkinson’s disease patients have depressive symptoms before the disease. 2.7 Other symptoms: fatigue, falling, weakness, weight loss, blurred vision, etc. 3. Popularize knowledge of the disease, early detection, early diagnosis, early prevention and treatment So far, there is no specific examination method to confirm the diagnosis of Parkinson’s disease in the early stage. Therefore, by popularizing knowledge of the disease and raising the level of understanding of the early clinical manifestations of Parkinson’s disease, we can hope to have early detection, early diagnosis and timely prevention and treatment. It is important to be familiar with the early symptoms of Parkinson’s disease, such as decreased sense of smell, easy fatigue, sleep disorders, memory loss, slower reaction time, frequent depression, mild tremor, and decreased expression. Patients and their family members who are familiar with these symptoms can recognize them in time and seek early medical attention in the hope of detecting the problem early. Clinicians who are familiar with the above symptoms will pay more attention to middle-aged and elderly patients, especially those with some of the above symptoms, and should pay more attention to observation and regular follow-up.