Children’s hands peeling may be due to physiological factors, may also be due to vitamin B deficiency, zinc deficiency and other pathological factors. 1. Physiological factors: usually due to children usually do not pay attention to skin care, or often play with sand, contact with some irritating substances; usually hand cream and hand sanitizer irritating too strong, is also one of the important factors. 2. Vitamin B deficiency: can lead to pellagra, mainly manifested as skin inflammation, inflammation of the tongue and intestinal inflammation, etc., and some patients will have mental anomalies and peripheral neuritis, etc., hand peeling can be one of the manifestations. 3. Zinc deficiency: zinc deficiency can lead to skin mucosal barrier damage. It is also an important factor that leads to the peeling of the hands, at the same time, there will be a decrease in appetite, decreased immunity, and in severe cases, there can be weight loss, malnutrition and other accompanying symptoms. Children’s hands peeling, there may be other reasons, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, give targeted treatment.