Patient: Can a balanced chromosomal translocation G,46,XY,t(4;7)(q25;p15) produce a healthy child? Is the deformity high Doctor: According to your chromosome examination report, you are a reciprocal translocation carrier between non-homologous chromosomes. In meiosis, through the pairing of homologous chromosomes, tetrasomes will be formed. Regardless of the locus of interchange, at least 18 types of gametes can be formed, and when they combine with normal gametes, 18 types of congeners can be formed, of which only one is normal (1/18) and one is a phenotypically normal translocation carrier (1/18), and only in these two cases can the embryo develop and give birth to a Only in these two cases can the embryo develop and give birth to a healthy child. The others are partially trisomic, partially monosomic or monosomic, monosomic and trisomic. Therefore, when your loved one is pregnant, you should take the chorionic villi at 11-13 weeks of pregnancy or go to the amniotic fluid at 16-23 weeks for a fetal chromosome test. This will prevent the birth of malformed fetuses.