It is incorrect to say that a plus urine protein does not require medication. This is because the causes of urine protein plus are different, so the treatment is also different. If it is caused by physiological factors, such as after strenuous exercise, or after exposure to heat sources or after staying up late, a routine urine test reveals a plus sign of urine protein, in this case, after the removal of physiological factors, the urine protein will turn negative, this situation does not need to take medicine. However, if diabetes or hypertension is the cause of a plus urine protein, it indicates the development of diabetic nephropathy or hypertensive kidney damage, which may require adjustment of treatment and the addition of drugs to slow down the progression of nephropathy. If it is caused by immune-related secondary nephritis, especially lupus nephritis, this condition requires not only medication, but also the application of more specific drugs, such as hormones and immunosuppressants. Because this disease is an autoimmune disease related to immunity, it produces a lot of antibodies to attack various organs throughout the body, which can cause multiple organ failure if not treated with medication. In case of chronic nephritis, it is necessary to look at the urine protein quantification, which is <0.3 grams, this situation does not require medication; more than 0.3 grams per day is recommended to start medication to control the amount of urine protein.