Whether entecavir has an effect on male preparation for pregnancy is now undetermined. Entecavir is an antiviral drug mainly used for chronic adult hepatitis B virus with active lesions, but according to the results of acute toxicity tests of pharmacological effects that have been available, its potential harm to the genitourinary system of men is still not very clear, so men who apply the drug to treat hepatitis B virus, need to consider all aspects of the decision to be made after trying to get pregnant. Mainly because the male sperm formation cycle is about 3 months, taking into account the uncertainty of the drug on the male reproductive system damage, it is recommended to wait until the hepatitis disease remains stable after stopping the drug for 3 months, and monitor the semen test and other reproductive examinations without obvious abnormalities, and then consider whether it is necessary to try to get pregnant. If there is a recurrence of hepatitis B, it is recommended that patients should follow the doctor’s instructions to use medication, so as to avoid the existence of side effects, and suffering from hepatitis B, the treatment also needs to be regularly to the hospital for retesting, found abnormalities also need further treatment.