Weakly positive antinuclear antibodies may be seen in normal older adults or may indicate the presence of an autoimmune disease, which may turn negative with treatment. Weakly positive antinuclear antibodies can be seen in some normal elderly people and can usually be followed up. Weakly positive antinuclear antibodies also indicate the presence of autoimmune diseases, such as rheumatoid arthritis, dry syndrome, systemic lupus erythematosus, etc., which can be treated with glucocorticosteroids or immunosuppressive drugs, such as prednisone, hydrocortisone, methotrexate, leflunomide, etc., and the antibodies can turn negative after treatment. Usually, we should quit smoking and alcohol, avoid spicy and stimulating food, appropriate exercise, and enhance the immunity of the body. It is recommended that patients go to the hospital in time, the test report should be interpreted by a professional doctor, after a clear diagnosis, follow the doctor’s instructions for medication.