Hand callus is mainly due to long-term friction and pressure, caused by the palm of the hand skin overgrowth, you can see the thick yellow patches, the serious will appear abnormal touch, in the clinic is mostly seen in the callus, and therefore need to be treated as follows: 1, strengthen the hand skin moisturizing, hydrating, skin care: in the treatment of the first need to strengthen the hand skin moisturizing, hydrating, skin care, you can apply the medical emollient milk 2, medication: every night before bedtime application of diluted white vinegar soak hands 20 minutes later, salicylic acid ointment and urea ointment mixed external, adhere to two months later, the callus on the hands will be slowly lost. 3, medical treatment: if after the above treatment did not see any improvement, you can also go to dermatology clinic for the treatment of liquid nitrogen freezing, but also to choose to the regular Triclinic hospitals for the treatment of medical treatments such as hydrazine needle treatment, photorejuvenation laser You can also choose to go to a regular tertiary hospital for medical treatment, such as hydrafacial injection, photorejuvenation laser treatment. During the treatment period, you need to avoid spicy and stimulating food and alcohol. You need to wear gloves to do housework to minimize the stimulation of the skin on your hands by washing liquid and detergent.