MTX, also known as methotrexate, was first synthesized in the 1940s and was initially used for the treatment of tumors, and was first used for the treatment of rheumatoid arthritis in 1951. In recent years, MTX, also known as methotrexate, has been recognized as one of the most effective anti-rheumatic drugs in clinical practice because it is fast-acting, easy to take, has relatively mild side effects, and has no long-term carcinogenic effects. Although the mechanism of action of methotrexate in the treatment of rheumatoid arthritis is not yet clear, its value in the treatment of rheumatoid arthritis is gaining more and more attention, and it is also used in the treatment of various rheumatic immune diseases like ankylosing spondylitis, reactive arthritis, vasculitis, systemic lupus erythematosus, etc.