Acne next to the mouth, need to clarify the disease and follow the doctor’s instructions to use the appropriate medication. If it is acne, you can use adapalene gel; folliculitis can use topical antibiotic ointment; herpes can use acyclovir ointment. 1. Acne: It is related to factors such as elevated androgen and increased sebaceous gland secretion during puberty, which can cause acne next to the mouth. It can be treated with topical medications such as adapalene gel and retinoic acid ointment. If necessary, oral minocycline, isotretinoin and other drugs. 2. Folliculitis: Bacterial infection caused by folliculitis can also lead to pimples next to the mouth, you can use erythromycin ointment, mupirocin ointment and other antibiotic ointment treatment. 3. Herpes: Herpes simplex virus infection caused by skin herpes, can also lead to pimples next to the mouth, you can use topical acyclovir ointment, penciclovir ointment and other antiviral drugs treatment. You can also take oral medications such as acyclovir and vasiclovir. There may be other reasons for pimples next to the mouth, it is recommended to go to the hospital to check the cause of the disease, and follow the doctor’s instructions to use medication.