There are many reasons for thirst in the middle of the night, it may be a normal physiological phenomenon, and it may be due to diabetes, uremia, environmental influences, etc. The specific situation is analyzed as follows. 1. Normal physiological phenomenon: If the patient consumes too much salty food for dinner, it will lead to water metabolism disorders in the body, in the middle of the night when you sleep, there will be thirst, for this phenomenon, we should improve our dietary habits in time, eat more light food, drink more water. 2. Diabetes: For diabetic patients, due to high blood glucose levels in the body, resulting in increased glucose content in the urine, plasma osmotic pressure increases, in the urine, will lead to a large loss of water in the body, the central nervous system is stimulated by the feeling of thirst, resulting in thirst at night, dry mouth symptoms, this phenomenon will be improved with the control of blood glucose levels. 3. Uremia: due to the lack of secretion of antidiuretic hormone in the patient’s body, or dysfunction, affecting the reabsorption of water by the kidneys, urine will be discharged in large quantities, resulting in loss of water, which will lead to the symptoms of thirst in the middle of the night. 4. Environmental impact: If the sleeping environment temperature is relatively high, the air humidity is lowered, it will cause the human body thermoregulation disorders, resulting in thirst in the middle of the night, daily to maintain the environmental temperature and properly adjust the indoor air humidity. If you exclude physiological phenomena still appear in the middle of the night thirst, you should consult a doctor in time, for the treatment of the original disease.