Positive HPV type 16 can turn negative on its own. HPV16 is one of the high-risk types of HPV. If you are continuously infected with HPV16 for more than one year, it will increase the probability of cervical cancer, anal cancer and cervical lesions. If the patient’s body resistance is relatively good, the HPV virus can be removed from the body through its own resistance, that is, automatically turn negative. Those with poorer resistance have a lower chance of becoming negative. If the patient does not turn negative for a long period of time, he/she needs to undergo cervical TCT to check for cervical lesions. If abnormal cervical lesions are present, he/she should also undergo colposcopic biopsy to rule out the possibility of cervical cancer or precancerous lesions. Then according to the results of the treatment, you can follow the doctor’s instructions to use interferon gel, cervical conization surgery and other treatments. It is recommended that the patient consult the doctor in time for further examination and actively cooperate with the doctor for treatment.